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Paget's disease of the breast or Paget disease of the breast (, rhymes with "gadget") (also known as Paget's disease of the nipple ) is a malignant condition that outwardly may have the appearance of eczema, with skin changes involving the nipple of the breast. The condition is an uncommon disease accounting for 1 to 4.3% of all breast cancers and was first described by Sir James Paget in 1874. The condition in itself often appears innocuous, limited to a surface appearance and it is sometimes dismissed, although actually indicative of underlying breast cancer.〔Thin, G. On the connection between disease of the nipple and areola and tumors of the breast. Trans Pathol Soc Lond 1881; 32:218.〕 ==Signs and symptoms== Paget's disease of the breast can affect the nipple and areola. Symptoms typically only affect one breast. Symptoms may include: * ''Skin.'' The first symptom is usually an eczema-like rash. The skin of the nipple and areola may be red, itchy and inflamed. After a period of time, the skin may become flaky or scaly. * ''Discharge.'' A discharge, which may be straw-colored or bloody, may ooze from the area. * ''Sensation.'' Some women have a burning sensation. These symptoms usually occur in more advanced stages, when serious destruction of the skin often prompts the patient to consult. Lumps or masses in the breast occur in 50% of the patients.〔(【引用サイトリンク】title=Paget's Disease of The Nipple )〕 In more advanced stages, the disease may cause tingling, increased sensitivity and pain.〔(【引用サイトリンク】title=Paget Disease of the Nipple: Questions and Answers )〕 * Nipple changes. The nipple may turn inwards (be inverted). * Breast changes. There may or may not be a lump in the breast, and there may be redness, oozing and crusting, and a sore that does not heal. The symptoms usually affect the nipple and then spread to the areola and then the breast. It is common for the symptoms to wax and wane. Most women do not visit the doctor because they assume Paget's disease to be minor contact dermatitis or eczema.〔(【引用サイトリンク】title=Breast Pagets Disease )〕 A lump or skin irritation that does not seem to heal for over a month indicates that attention by a specialist is needed. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Paget's disease of the breast」の詳細全文を読む スポンサード リンク
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